Uses of The Danazol:
To treat endometriosis (an abnormal condition involving the inner lining of the uterus).
To treat fibrocystic breast disease (cysts or lumps in the breast).
To treat hereditary angioedema (swelling of the abdominal organs and tissue, extremities, throat, and airway).
Unlabeled Uses: Occasionally doctors may prescribe danazol for early puberty, development of breasts (in males), and heavy menstrual flow. It has also been studied for the treatment of anemia.
Diabetes: Insulin requirements may increase. Abnormal glucose (sugar) tolerance tests may occur. Monitor urine and blood sugar levels.
Fluid retention: Danazol can cause fluid retention, which may aggravate epilepsy, migraine, or heart or kidney disease. Use with caution.
Women: Women taking danazol may experience masculinizing effects, including acne, edema (fluid retention), increased hair growth, decrease in breast size, deepening of the voice, oily skin or hair, weight gain, and enlargement of the ciltoris. These effects may not go away when the drug is stopped.
Pregnancy: Do not use during pregnancy. The risk of use in a pregnant woman clearly outweighs any possible benefit. Masculinization of a female fetus may occur.
Breastfeeding: Do not use if you are breastfeeding.
Children: Safety and effectiveness have not been established.
Lab Tests: Lab tests may be required to monitor treatment. Tests include urine and blood sugar levels.
Drug Interactions:
Tell your doctor or pharmacist if you are taking or planning to take any overthe-counter or prescription medications or dietary supplements while taking this drug. Drug doses may need to be modified or a different drug prescribed. The following drugs and drug classes interact with this drug:
Carbamazepine (eg, Tegretol)
Insulin warfarin (eg, Coumadin)
Side Effects of The Danazol:
Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility.
If you experience any effects different from those listed, do not hesitate to contact your doctor or pharmacist. It could be a sign of a rare or unusual side effect that requires treatment. Possible side effects include:
Masculinizing Androgenic Effects - Acne; fluid retention (edema); decrease in breast size; deepening of the voice; mild abnormal growth of fine body hair; oily skin or hair; weight gain; menstrual changes or pain; hair loss; hoarseness; sore throat.
Signs of Low Estrogen Levels - Flushing; sweating; vaginitis (itching, dryness, burning, and vaginal bleeding); nervousness; emotional instability.
Men - Reduction in sperm count; semen changes (decreased volume and viscosity).
Miscellaneous - Liver dysfunction; yellowing of the skin; abnormal lab tests; severe headache (intra cranial hypertension); nausea; vomiting; vision disturbances; hives; itching; rash; blood clots; fatigue; sleep disorder; anxiety, constipation; joint pain.
