Danazol for endometriosis

Jan 20, 2010

Danazol Description

Generic Name : DANAZOL

Why it is prescribed: Danazo l is used to treat endometriosis, a disease that causes infertility, pain before and during menstrual periods, pain during and after sexual activity, and heavy or irregular bleeding. Danazol also is used to reduce breast pain, tenderness, and nodules in fibrocystic breast disease and to treat various medical conditions.

When it is to be taken: Danazol usually is taken twice a day. Women should take the first dose during a menstrual period and take it continuously thereafter. Follow the instructions on your prescription label carefully. Do not stop taking danazol until your doctor tells you to do so. If you have fibrocystic breast disease, breast pain and tenderness usually improve during the first month that you take danazol and go away in two to three months; nodules should improve in four to six months. If breast nodules persist or enlarge, contact your doctor.

How it should be taken: Danazol comes in the form of capsules. Your prescription label tells you how much to take at each dose.

Special Instruction :
1. Keep all appointments with your doctor and the laboratory. You probably will have periodic blood tests;men also will have semen tests.
2. Your doctor may decrease your dose, depending on your response to the drug.
3. If you forget to take a dose, take it as soon as you remember. However, if you remember a missed dose at the time you are scheduled to take the next dose, omit the missed dmose completely. Do not take a double dose.

Side Effects :
1. Acne, decrease in breast size, deepening of voice, weight gain, swelling, oily skin or hair, hair growth in unusual amounts and places. Contact your doctor.
2. Flushing;sweating; vaginal dryness, burning, itching, or bleeding; nervousness; depression; irritability. If these effects persist or severe, contact your doctor.
3. Skin rash, yellowing of skin or eyes. Contact your doctor.

Other Precautions :

1. Before you take danazol, tell your doctor if you have migraine headaches;heart, liver, or kidney disease; or a history of epileptic seizures or breast cancer.
2. Before you take this drug, tell your doctor if you are pregnant or breast-feeding. Danazol should not be taken during pregnancy; it can harm the unborn baby.
3. Use a reliable method of birth control, other than birth-control pills, while taking this drug and until you have had at least one menstrual period after stopping the drug.
4. Danazol can cause menstrual periods to stop entirely, but they usually resume within two to three months after danazol treatment.
5. If you become pregnant while taking danazol, contact your doctor immediately.
6. Do not allow anyone else to take this medication.

Storage Conditions : Keep this medication in the container it came in, tightly closed, and out of the reach of children. Store it at room temperature.

Dec 9, 2009

Danazol Oral Uses

Danazol blocks the release of gonadotropin, a hormone secreted from the pituitary gland. The result of this blocking effect is to depress the output of two other hormones, FSH (follicle stimulating hormone) and LH (luteinizing hormone). FSH and LH are important in many functions of the sex glands, including ovulation.

Uses of The Danazol:

To treat endometriosis (an abnormal condition involving the inner lining of the uterus).

To treat fibrocystic breast disease (cysts or lumps in the breast).

To treat hereditary angioedema (swelling of the abdominal organs and tissue, extremities, throat, and airway).

Unlabeled Uses: Occasionally doctors may prescribe danazol for early puberty, development of breasts (in males), and heavy menstrual flow. It has also been studied for the treatment of anemia.

Diabetes: Insulin requirements may increase. Abnormal glucose (sugar) tolerance tests may occur. Monitor urine and blood sugar levels.

Fluid retention: Danazol can cause fluid retention, which may aggravate epilepsy, migraine, or heart or kidney disease. Use with caution.

Women: Women taking danazol may experience masculinizing effects, including acne, edema (fluid retention), increased hair growth, decrease in breast size, deepening of the voice, oily skin or hair, weight gain, and enlargement of the ciltoris. These effects may not go away when the drug is stopped.

Pregnancy: Do not use during pregnancy. The risk of use in a pregnant woman clearly outweighs any possible benefit. Masculinization of a female fetus may occur.

Breastfeeding: Do not use if you are breastfeeding.

Children: Safety and effectiveness have not been established.

Lab Tests: Lab tests may be required to monitor treatment. Tests include urine and blood sugar levels.

Drug Interactions:

Tell your doctor or pharmacist if you are taking or planning to take any overthe-counter or prescription medications or dietary supplements while taking this drug. Drug doses may need to be modified or a different drug prescribed. The following drugs and drug classes interact with this drug:

Carbamazepine (eg, Tegretol)
Insulin warfarin (eg, Coumadin)

Side Effects of The Danazol:

Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility.

If you experience any effects different from those listed, do not hesitate to contact your doctor or pharmacist. It could be a sign of a rare or unusual side effect that requires treatment. Possible side effects include:

Masculinizing Androgenic Effects - Acne; fluid retention (edema); decrease in breast size; deepening of the voice; mild abnormal growth of fine body hair; oily skin or hair; weight gain; menstrual changes or pain; hair loss; hoarseness; sore throat.

Signs of Low Estrogen Levels - Flushing; sweating; vaginitis (itching, dryness, burning, and vaginal bleeding); nervousness; emotional instability.

Men - Reduction in sperm count; semen changes (decreased volume and viscosity).

Miscellaneous - Liver dysfunction; yellowing of the skin; abnormal lab tests; severe headache (intra cranial hypertension); nausea; vomiting; vision disturbances; hives; itching; rash; blood clots; fatigue; sleep disorder; anxiety, constipation; joint pain.

Sep 4, 2009

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